Basic Immunology Final; practice questions
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c.
proto-oncogenes
d.
sarcoma genes
e.
all of the above
7.
When skin is transplanted in syngeneic exchanges there is a stage where the skin can appear pinker than
once the graft has become well established. The cause of this change is often a result of
a.
vascular leakage and bruising
b.
excess capillary overgrowth caused by angiogenic factors
c.
increased red pigmentation in the transplanted tissue
d.
all of the above
e.
none of the above
8.
The human condition DiGeorge syndrome is a disease that results from a lack of the thymus. What
mouse mutation is an example of the same defect in immune competence?
a.
SCID
b.
nude
c.
NOD
d.
beige
e.
motheaten
9.
HIV infection has been successfully treated in a few human patients by whole body irradiation followed
with transplantation of hematopoietic stem cells from a CCR5 mutant donor. Why might this work?
a.
the absence of CCR5 means that the patient is unable to sustain any viral infection.
b.
since CCR5 is a coreceptor for HIV, the speed of HIV viral infection is diminished, and normal
hematopoiesis by the transplanted immune cells can keep up with cell death caused by the virus
c.
CCR5 is responsible for chemotactic movement, enabling rapid responses to the viral infection
d.
CCR5 is an important part of class I antigen presentation, enabling CTL killing of virally
infected cells
e.
none of the above are true
10.
Why do immune cells die or become dysfunctional as a result of HIV infection?
a.
Infected cells become targets for CTL killing
b.
HIV-infected cells can cause multinucleated syncytia that lose functional capacity
c.
HIV-infected cells can autofuse, resulting in highly vesiculated cells that lose functional capacity
d.
all of the above
e.
none of the above
11.
In analyzing the genotypes of Tasmanian Devils, the authors of the paper compared a number of
microsatellite loci. Microsatellite are
a.
a small region of replicated DNA motifs that can range from 1-6 base pairs in length and are
repeated in short tandem repeats of 5-50 sequences.
b.
small fragments of DNA that are produced by the endonucleases of apoptosis
c.
fragmented DNA produced by oncornavirus infection leading to cancer
d.
repetitive genetic elements that encode transcription factors
e.
all of the above represent different examples of microsatellites