Question 5. 
 
A 42-year-old man presented with a 1-month history of altered personality and increased 
seizure frequency. An MR scan of brain demonstrated an enhancing lesion in the right frontal 
lobe. Histology revealed a grade 3 oligodendroglioma, with loss of heterozygosity of 1p/19q. 
 
What is the most appropriate treatment? 
 
A  chemoradiation with temozolomide  
B cranial 

irradiation 

C  craniospinal irradiation  
D  procarbazine, vincristine and lomustine (PCV) 
E temozolomide