Study Set Content:
antibodies in the serum that reacts to the ABO blood group are naturally formed due to stimulation of the immune system, commonly from?
Foods, Bacteria, Microorganisms, Viruses
There are how many structural/ functional domains in a mitotic chromosome?
4
Condensin is required for successful completion of mitosis and for the formation of mitotic chromosome in vivo.
FALSE
what group/ race of people have the highest proportion of Blood Type A?
CAUCASIANS
DNA topoisomerase II is one of the most abundant Non-histone chromosomal proteins but is NOT important for mitotic chromosome formation.
TRUE
What protein makes up about 50% of all the proteins that compose the chromosome? Answer in CAPITAL letters.
HISTONES
11. What sequence of the DNA characterizes the human telomeres? Answer in CAPITAL letters
TTAGGG
What are the 3 peripheral proteins that are necessary for a timely and efficient alignment of chromosomes during prometaphase?
NUCLEOLIN, NUCLEOPHOSMIN, RRS1
What protein makes up the major component of the centromere?
CENP, CENP-A
What model is proposed and is consistently accepted for chromatin packing? Answer in CAPITAL letters
SOLENOID MODEL
What do you call chromosomes whose centromere assembles as diffuse centromere across the whole chromosome?
HOLOCENTRIC CHROMOSOMES
_______________ chromosomes have centromeres that assemble at a single localized site in the chromosome.
MONOCENTRIC CHROMOSOMES
The unifying characteristics of most eukaryotic centromere is the presence of __________.
CENP-A
What is the field of genetics that describe the changes in the gene expression without the corresponding change in the DNA sequence of a cell?
EPIGENETICS
This class of the monocentric chromosomes has its centromere with specific ordered sequence. What type of centromere is this? Answer in CAPITAL letter
POINT CENTROMERE
What is the epigenetics hallmark of centromere identity?
CENP-A
What are the 2 major components of the perichromosomal layer? (_____________ and ______________).
RIBOSOMAL AND NUCLEOLAR PROTEINS
_____________ Centromere are those found in monocentric chromosomes which are characterized by DNA sequence in tandem repeats.
REGIONAL CENTROMERE
The most critical step for the attachment of the spindle fiber to the kinetochore is the deposition of the CENP-A to the centromeric site. What event in mitosis is this critical step VERY important?
SEGREGATION, CHROMOSOMAL SEGREGATION
The position of the human centromere in each chromosome is heritable, independently of the underlying DNA sequence.
TRUE
