Heparin-Induced Thrombocytopenia 

(HIT)



HIT



Associated with administration of heparin



Develops when the body develops an antibody, or allergy 

to heparin



Heparin (paradoxically) causes thrombosis



Immune mediated response that casues intense platelet 

activation and relaese of procoaggulation particles.



Clinical features



Thrombocytopenia



Possible thrombosis after heparin therapy



Can be triggered by any type, route or amount of heparin

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