Basic Immunology Final; practice questions
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MCB 4211,
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e.
there is no evidence of non-mutagenic events causing cancer
29.
What kind of event can support tumor growth past a limit imposed by diffusion of nutrients?
a.
angiogenesis
b.
complement inactivation
c.
macrophage activation
d.
telomerase inactivation
e.
all of the above
30.
Apoptosis ordinarily serves to prevent the development of an autoimmune response to the dying cells.
This is because:
a.
The apoptosis of macrophages will limit their ability to present antigen
b.
Apoptotic cell death eliminates the inter-digital tissues in the hands of the fetus
c.
Apoptosis prevents the release of immunogenic intracellular antigens that would
d.
promote inflammation.
e.
Antibodies to the Fas ligand and receptor are formed
f.
Necrosis follows the apoptotic process
31.
Genome Wide Associational Studies (GWAS) can be used to address which of the following
experimental questions?
a.
What are the loci associated with risk for the onset of Type 1 diabetes?
b.
What are the mechanisms of transformation that a carcinogen employs to produce lung cancer?
c.
What is the effect of a CD28 mutation on CTL cell mediated cytotoxicity?
d.
What cytokines are overexpressed in individuals that have inflammatory bowel disease?
e.
All of the above
32.
Why does the CD4/CD8 ratio flip as patients progress in AIDS?
a.
the number of CD4 cells increase as the disease progresses
b.
CD8 cells are depleted as they attach the virus
c.
the number of macrophages expressing CD4 increases with disease progression
d.
the number of each cell type do not change, but the ratio does
e.
CD4 cells decrease in number for several reasons, including CTL killing of virally infected
targets
33.
What is the significance of TGF-b induction by MT in the required reading paper that explored the anti-
inflammatory effect of MT in a model of rheumatoid arthritis?
a.
this cytokine usually operates as an immunosuppressive cytokine that blocks the progression of
some inflammations
b.
this cytokine activates the complement cascade
c.
this cytokine is able to block the enzymatic activity of cyclooxygenase-2
d.
this cytokine depletes the T cells in the thymus
e.
the paper described all of the changes listed above
34.
In the paper describing MT as a therapeutic agent in the development of rheumatoid arthritis, the
experiments included a measure of proliferation when mice were treated with vehicle or with MT, and