• Therapy is often initiated with a lower

than-usual adult dose.

• Dose adjustment may be required based

on the therapeutic response.

• The patient’s physical condition may

determine the drug dose and the route of

administration employed.

The dose may be determined, in part, on the

patient’s weight, body surface area, health and

disease status, and pharmacokinetic factors.

• Concomitant drug therapy may affect drug/dose

effectiveness.

• A drug’s dose may produce undesired adverse

effects and may affect patient compliance.

• Complex dosage regimens of multiple drug

therapy may affect patient compliance.