Pharmacrystal

www.pharmacrystalniper.blogspot.com

www.pharmacrystalniper.blogspot.com

13

Pharmacokinetic Distribution:

Basics

1.1) Which of the following would receive drug slowly?
       a) Liver
       b) Brain
       c) Fat
       d) Muscle
       e) Kidney
1.2) Which of the following is the least important for passage through capillary walls but
the most important for passage through the cell wall?
       a) Molecular size
       b) Lipid solubility
       c) Diffusion constant
       d) pH
       e) pKa
1.3) Which of the following is the most important for movement through capillary walls?
       a) Molecular size
       b) Lipid solubility
       c) Diffusion constant
       d) pH
       e) pKa
1.4) Which of the following locations would most trap a lipid soluble drug?
       a) Blood
       b) Intestines
       c) Brain
       d) Stomach
1.5) What type of drugs can cross the blood-brain barrier (BBB)?
        a) Large and lipid-soluble
        b) Large and lipid-insoluble
        c) Small and lipid-soluble
        d) Small and lipid-insoluble
2.1) Acidic drugs, such as phenytoin, bind primarily to which of the following plasma
proteins?
        a) 



(AFP)

        b) GC Globulin
        c) Albumin
        d) 



glycoprotein (AAG)

        e) Transcortin
2.2) Basic drugs, such as lidocaine, bind primarily to which of the following plasma
proteins?
        a) 



(AFP)

        b) Gc-Globulin (GcG)
        c) Albumin
        d) 



glycoprotein (AAG)

        e) Transcortin
3.1) A decrease in drug-protein binding will lead to which of the following?
        a) Decrease in the unbound drug concentration
        b) Increase in free drug