Pharmacrystal
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c) Increase in rate of drug elimination
d) Decrease in volume of distribution
3.2) A patient presents with acute-onset cirrhosis of the liver. They are found to have
hypoalbuminemia. In severe cirrhosis it is expected that AAG will be decreased, but the
patient presents with increased AAG due to the inflammatory response. Which of the
following is the most likely?
a) Increased acidic drug binding and increased basic drug binding
b) Increased acidic drug binding and decreased basic drug binding
c) Decreased acidic drug binding and increased basic drug binding
d) Decreased acidic drug binding and decreased basic drug binding
3.3) Which of the following is NOT a site of loss (where drug is not used)?
a) Fat
b) GI tract
c) Muscle
d) Site lacking receptors
4.1) Which of the following locations can accumulate lipid-soluble drugs, has little or no
receptors, and can hold distributed drugs like barbiturates?
a) Liver
b) Kidney
c) Brain
d) Fat
e) Fetus
4.2) Which of the following locations has high blood flow and is a site of excretion?
a) Liver
b) Kidney
c) Brain
d) Fat
e) Fetus
4.3) Anything affecting renal perfusion will affect drug delivery to the kidney, drug
excretion, and drug levels in the blood.
a) True
b) False
4.4) Which of the following can be treated with drugs due to a leaky area in the blood-
brain barrier near the medulla?
a) Seizures
b) Shivers
c) Diarrhea
d) Nausea
e) Vomitting
4.5) What is the approximate lag time for equilibration between maternal blood and fetal
tissues?
a) 20 mins
b) 40 mins
c) 1 hour
d) 2 hours
e) 6 hours
Match the body compartment with the volume, assuming a 70kg male patient:
5.1) Total bodya) 4
5.2) Plasmab) 10
5.3) Interstitialc) 14
5.4) Extracellulard) 28
5.5) Intracellulare) 42
5.6) If protein plasma binding is decreased, how will volume of distribution be affected?