Pharmacrystal

www.pharmacrystalniper.blogspot.com

www.pharmacrystalniper.blogspot.com

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2.4) For zero-order drug elimination, half-life t(1/2) is ____ at two places on the curve
and a constant ____ is lost per unit time.
         a) Equal; Amount
         b) Equal; Percentage
         c) Not equal; Amount
         d) Not equal; Percentage

2.5) If a drug with a 2-hour half life is given with an initial dose of 8 mcg/ml, assuming
first-order kinetics, how much drug will be left at 6 hours?
         a) 8 mcg/ml
         b) 4 mcg/ml
         c) 2 mcg/ml
         d) 1 mcg/ml
         e) 0.5 mcg/ml

3.1) What are the units for steady-state concentration (Css), or infusion rate over
clearance?
         a) mg/min
         b) ml/min
         c) mg/ml
         d) ml/mg
         e) min/mg

3.2) What percentage of the steady-state drug concentration is achieved at 3.3 * t(1/2)?
         a) 10%
         b) 25%
         c) 50%
         d) 75%
         e) 90%

4.1) Increasing the rate of infusion changes the time necessary to reach the steady-state
concentration.
        a) True
        b) False

4.2) An injection of two units of a drug once-daily (qd) will yield the same steady-state
concentration as an injection of one unit of a drug twice-daily (bid).
        a) True
        b) False

5.1) Which of the following drugs would most likely need a loading dose to help reach
therapeutic levels?
        a) Acetaminophen, t(1/2) = 2 h
        b) Aspirin, t(1/2) = 15 m
        c) Tetracycline, t(1/2) = 11 h
        d) Digitoxin, t(1/2) = 161 h
        e) Adenosine, t(1/2) = 10 s