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19

5.2) A target concentration of 7.5 mg/L of theophylline is required for a 60 kg patient.
What is the loading dose, given the following: Vd = 0.5 L/kg, Cl = 0.04 L/kg/hr, t(1/2) =
9.3 hr?
        a) 0.5 L/kg * 60 kg * 7.5 mg/L = 225 mg/h, infusion
        b) 0.5 L/kg * 60 kg * 7.5 mg/L = 225 mg, bolus
        c) 0.04 L/kg/hr * 60 kg * 7.5 mg/L = 18 mg/h, infusion
        d) 0.04 L/kg/hr * 60 kg * 7.5 mg/L = 18 mg, bolus

5.3) A target concentration of 7.5 mg/L of theophylline is required for a 60 kg patient.
What is the steady state maintenance dose, given the following: Vd = 0.5 L/kg, Cl = 0.04
L/kg/hr, t(1/2) = 9.3 hr?
        a) 0.5 L/kg * 60 kg * 7.5 mg/L = 225 mg/h, infusion
        b) 0.5 L/kg * 60 kg * 7.5 mg/L = 225 mg, bolus
        c) 0.04 L/kg/hr * 60 kg * 7.5 mg/L = 18 mg/h, infusion
        d) 0.04 L/kg/hr * 60 kg * 7.5 mg/L = 18 mg, bolus

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