Pharmacrystal

www.pharmacrystalniper.blogspot.com

www.pharmacrystalniper.blogspot.com

7

7.4) Although morphine (Avinza, Oramorph SR, MS Contin) is well-absorbed when
administered orally (PO), how much of the drug is metabolized on its first pass through
the liver?
        a) 90%
        b) 70%
        c) 50%
        d) 30%
        e) 10%
7.5) For a generic drug to be bioequivalent to an innovator drug (per FDA), it must be
measured in ____ of subjects to fall within ____ of the mean of the test population
bioavailability.
        a) 50; 50
        b) 80; 20
        c) 20; 80
        d) 95; 5
        e) 5; 95
7.6) Using the FDA bioequivalence rule, how much variation could a generic drug
potentially have from an innovator and still be considered equivalent?
        a) 100%
        b) 20%
        c) 40%
        d) 60%
        e) 80%
8.1) Which of the following is NOT a pharmacokinetic process?
        a) Alteration of the drug by liver enzymes
        b) Drug metabolites are removed in the urine
        c) Movement of drug from the gut into general circulation
        d) The drug causes dilation of coronary vessels
        e) The drug is readily deposited in fat tissue
8.2) Which of the following can produce a therapeutic response? A drug that is:
        a) Bound to plasma albumin
        b) Concentrated in the bile
        c) Concentrated in the urine
        d) Not absorbed from the GI tract
        e) Unbound to plasma proteins
8.3) Which of the following most correctly describes steroid hormones with respect to
their ability to gain access to intracellular binding sites?
        a) They cross the cell membrane via aqueous pores
        b) They have a high permeability coefficient
        c) They are passively transported via membrane carriers
        d) They require vesicular transport
        e) Their transport requires the hydrolysis of ATP