Study Set Content:
AA
– Arachidonic acid
COX
Cyclooxygenase
DHET -
Dihydroxyeicosatrienoic acid
EET
Epoxyeicosatetraenoic acid
HETE –
Hyxyeicosatetraenoic acid
HPETE-
Hydroxyperoxyeicosatetraenoic acid
LTB- LTC
Leukotriene B, C, etc
LOX
Lipoxygenase
LXA, LXB
Lipoxin A, B
NSAID
Nonsteroidal anti-inflammatory drug
PGE, PGF
Prostaglandin E, F, etc
PLA, PLC
Phospholipase A, C
TXA- TXB –
Thromboxane A, B
the primary source of
vascular prostacyclin (PGI 2)
Endothelial COX-2
important for normal renal
development and maintenance of function.
Renal COX-2
inhibition of the COXs.
Nonsteroidal anti-inflammatory drug (NSAIDs)
slightly selective for
COX-1
Indomethacin and sulindac
approximately
equipotent on COX-1 and COX-2.
Meclofenamate and ibuprofen
inhibits both enzymes covalently.
Aspirin acetylates-
Low doses (
COX-1
