Study Set Content:
prevents formation of C3 convertases
DAF
inhibits formation of the membrane attack complex
CD59
inhibits formation of the membrane attack complex
CD59
An acquired deficiency of the enzyme that creates GPI anchors leads to deficiency of these regulators and excessive complement activation and lysis of red cells (which are sensitive to complement mediated cell lysis) in the disease called
Paroxysmal Nocturnal Hemoglobinuria
is a circulating glycoprotein that inhibits the alternative pathway of complement activation by promoting the cleavage and destruction of C3b and the turnover of the C3 convertases
Complement H Factor
phospholipid-derived mediator that was discovered as a factor that caused platelet aggregation
Platelet-Activating Factor (PAF)
causes vasoconstriction and bronchoconstriction, and at low concentrations it induces vasodilation and increased venular permeability
PAF
cleavage products of fibrin (fibrinopeptides) can stimulate inflammation
Products of Coagulation
A link between the coagulation pathway and inflammation is supported by the presence of
Protease-activated receptors
are vasoactive peptides derived from plasma proteins, called kininogens
Kinins
Kinins are derived from plasma proteins by the action of specific proteases called,
Kallikreins
increases vascular permeability and causes contraction of smooth muscle, dilation
of blood vessels, and pain when injected into the skin
Bradykinin
Bradykinin is short lived since it is inactivated by the enzyme called
Kininase
secreted by sensory nerves and various leukocytes and may play a role in the initiation and regulation of inflammatory responses
Neuropeptides
are produced in the central and peripheral nervous systems.
Substance P and Neurokinin A
The lymphatics may become secondarily inflamed
Lymphangitis
The draining lymph nodes
Lymphadenitis
Phagocytosis involves sequential step
- Recognition and attachment of the particle to be ingested by the leukocyte;
- Engulfment, with subsequent formation of a phagocytic vacuole; and
- Killing of the microbe and degradation of the ingested material.
Phagocytic Receptors include
Mannose receptors, Scavenger Receptors, and receptors for various opsonins
a lectin that binds terminal mannose and fucose residues of glycoproteins and glycolipids
Macrophage Mannose Receptors
