Study Set Content:
An organism, a molecule or part of a molecule that is recognized by the immune system
Antigens
Antigens could be what in origin?
Simple or complex, carbohydrate, protein, or synthetic in origin
Antigens are also known as?
antigenic determinant
Smallest part of an antigen that is seen by somatically generated by what cells?
B and T cell
Antigens are divided into 3 categories which are:
Immunogens, Haptens and Tolerogens
Basic recognition unit
Epitopes
Contain epitopes that both induce an immune response and are the targets of that response.
Immunogens
Small, normally non-immunogenic molecules, usually of non-biologic origin, that behave like synthetic epitopes.
Haptens
Substance or antigen that evokes a specific, positive immune response.
Immunogens
True or False:
Haptens are antigens that can bind to immune receptors but CANNOT by themselves induce a specific immune response, hence, they are IMMUNOGENIC.
False; not Immunogenic
Induce adaptive immune responsiveness.
Tolerogens
Exposure to tolerogens can result to what?
diminished response rather than an enhanced one
Nature of Complex Antigens
- Linear Determinant
- Conformational Determinant
- Neoantigenic Determininant
epitope formed by juxtaposition of several structural units in a folded molecule
Conformational Determinant
epitope formed by several adjacent structural units
Linear Determinant
epitope formed from modification of a complex molecule, which in its native conformation, the region is not normally accessible
Neoantigenic Determinant
Determinant lost by denaturation
Conformational Determinant
Ig binds to determinant in denatured protein only
Linear determinant
Ig binds to determinant in both native and denatured protein
Linear determinant
Determinant near site of proteolysis
Neoantigenic determinant
