Patients with ischemic heart disease or
renovascular hypertension may be at increased risk
if B blockade is suddenly
interrupted.
rather than abrupt cessation of
dosage when these drugs are discontinued,
especially drugs with short halflives, such as propranolol and metoprolol.
Gradual tapering
The incidence of hypoglycemic episodes
exacerbated by B-blocking agents in diabetics is
unknown.
offer some advantage in
these patients, since the rate of recovery from
hypoglycemia may be faster compared with that in
diabetics receiving nonselective B-adrenoceptor
antagonists.
Beta 1 selective antagonists