Study Set Content:
Describes the actions of a drug on the body, and
includes the principle of receptor interactions, mechanisms
of therapeutic and toxic action, and dose-response
relationship.
PHARMACODYNAMICS
The component of a cell or organism that interacts with a
drug and initiates the chain of events leading to the drug’s
observed effects.
RECEPTOR
Receptor concept
Receptors largely determine the quantitative relations
between the (blank)and
(blank)
dose or concentration of the drug, and pharmacologic effects.
The receptor's (blank) a drug determines the
concentration of drug required to form a significant
number of drug-receptor complexes,
affinity for binding
The receptor's affinity for binding a drug determines the
concentration of drug required to form a significant
number of drug-receptor complexes, and the total
number of receptors may limit the (blank) a drug
may produce.
maximal effect
Receptors are responsible for the (blank) of drug
action.
selectivity
The (blank)of a drug
determine whether - and with what affinity - it will bind
to a particular receptor among the vast array of
chemically different binding sites available in a cell,
tissue, or patient.
molecular size, shape, and electrical charge
Receptors mediate the actions of pharmacologic
agonist and antagonist
interfere with the ability of an agonist to
activate the receptor.
Antagonist
activate the receptor to signal as a direct result
of binding to it.
Agonist -
The effect of a so-called (blank) on a cell or in a patient depends entirely on it
preventing the binding of agonist molecules and blocking
their biological actions.
“pure”
antagonist
If a ligand for an orphan receptor is later discovered, the receptor is referred
to as an
an "adopted orphan".
– mediate the actions of endogenous
chemical signals such as neurotransmitters, autocoids, and
hormones.
Regulatory Proteins
– may be inhibited (or, less, commonly, activated)
by binding a drug (e.g. dihydrofolate, reductase, the receptor
for the antineoplastic drug methotrexate.)
Enzymes
the receptor
for the antineoplastic drug methotrexate.)
dihydrofolate, reductase,
the
membrane receptor for cardioactive glycosides.
Transport Proteins
example of transport proteins
Na+ / K + ATPase),
Responsible for functions ranging from the cell’s shape, movement, and
provides support to major structures like the bones, cartilage, hair, and
muscles.
Structural Proteins
the receptor for
colchicine, an anti-inflammatory agent).
Tubulin
Other examples of structural proteins are (blank)
which forms the connective tissue framework of muscles, bones, tendons,
skin and cartilage.
keratin, actin, myosin, and collagen
