Study Set Content:
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that act through different receptor

mechanisms and produce different toxicities may allow

lowering the dose of the first drug, thus limiting its


Adjunctive Drugs

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222- Flashcard

Use of other (blank) added to

glucocorticoids in treating inflammatory disorders.

immunosuppressive agents

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223- Flashcard

Third, selectively of the drug’s actions may be increased by

(blank) drug available to

receptors in different parts of the body.

manipulating the concentration of

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224- Flashcard

Beneficial and Toxic effects mediated by different types of receptors

Several other drugs were discovered by exploiting therapeutic or toxic effects of chemically(blank) in a clinical context

similar agents

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Examples include

quinidine, sulfonylureas, thiazide diuretics,

tricyclic antidepressants, opioid drugs, and phenothiazine


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Often the new agents turn out to interact with receptors for

(blank) (eg. opioids and phenothiazines for

endogenous opioid and dopamine receptors, respectively.

endogenous substances

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so-called because their ligands are

presently unknown, which may prove to be useful targets for

the development of new drugs.

“Orphan” Receptors

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1: A lipid-soluble

chemical signal crosses the plasma membrane and acts on an



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2: the

signal binds to the (blank) of a transmembrane protein, thereby

activating an (blank) of its cytoplasmic domain;

extracellular domain, enzymatic activity

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3: the signal binds to

the extracellular domain of a transmembrane receptor bound to a separate

(blank), which it activates;

protein tyrosine kinase

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4: the signal binds to and directly

regulates the opening of an

ion channel

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the signal binds to a cell-surface

receptor linked to an effector enzyme by a


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(blank) cGMP concentration causes

relaxation of vascular smooth muscle by a

kinase-mediated mechanism that results in

(blank) of myosin light chains.


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