Study Set Content:
synthetic chelating agent used to tie up or sequester iron and copper ions so that they cannot catalyze the oxidative degradation of ascorbic acid in fruit juices and in drug preparations
Ethylenediaminetetraacetic acid (EDTA)
Widely used to sequester and remove calcium ions from hard water.
EDTA
bonding between a polydentate ligand and a central atom as in a chelate complex.
Sequestration -
Organic coordination compound or molecular complex consists of constituents held together by
weak forces of the donor-acceptor type or by hydrogen bonds.
Many organic complexes are so weak that they cannot be separated from their solutions as
definite compounds
Many organic complexes are so weak that they cannot be separated from their solutions as definite compounds, and they are often difficult to detect by
chemical and physical means
The difference between a donor-acceptor and a charge transfer complex is that: o in the charge transfer complex (blank) makes the main contribution to complexation
resonance
whereas o in the donor-acceptor
London dispersion forces and dipole-dipole Interactions
r, London dispersion forces and dipoledipole Interactions contribute more to the stability of the
complex
Weak donor-acceptor complex or molecular complex
D---A
London dispersion forces and dipole-dipole interaction
D---A
Charge transfer complex
D*----A*
resonance
D*----A*
lodine forms(blank)charge transfer complexes with the drugs:
1:1
used against alcohol addiction
Disulfiram
- a sedative-hypnotic and anticonvulsant
Clomethiazole
-antifungal agent
Tolnaftate
Each of these drugs possesses a
nitrogen-carbon-sulfur moiety
Each of these drugs possesses a nitrogen-carbon sulfur moiety, and a complex may result from the transfer of charge from the pair of free electrons on the
nitrogen and/or sulfur
Each of these drugs possesses a nitrogen-carbonsulfur moiety, and a complex may result from the transfer of charge from the pair of free electrons on the nitrogen and/or sulfur atoms of these drugs to the
antibonding orbital
