Study Set Content:
· It is the deposition of Crystals
from a solution
Crystallization
· a fixed and rigid
arrangement of atoms, molecules
or ions.
Lattice
· A method of purifying organic substances through the
difference in solubility at different temperatures.
· Two crystallization process was performed.
Recrystallization
· Main factor that affects cryztallization
Solubility
Aniline
· It is used to make dyes, drugs, explosives,
plastics, and photographic and rubber
chemicals.
Aniline(C6H5N2)
· First obtained in 1826 by destructive
distillation of indigo
Aniline(C6H5N2)
Acetic Anhydride (CH3CO)2O
· A colorless liquid with a pungent vinegar-like odor
· Boiling point is 10C and 140C
· Melting point is 73C
Acetic Anhydride (CH3CO)2O
· From Indigofera anil
· Prepared commercially by catalytic
hydrogenation of nitrobenzene or by the
action of ammonia on chlorobenzene.
· If heated with organic acids, it will yields
anilides.
Aniline(C6H5N2)
· Soluble in ether, chloroform and benzene
· Density: 1.082 g/ml in liquid state
· Molecular weight: 102.09 g/mol
Acetic anhydride
· Use for conversion of cellulose-to-cellulose acetate
which is a component of photographic film and other
coated materials.
· Plays an important role in acetylation of aniline to
form acetanilide
Acetic Anhydride (CH3CO)2O
Acetanilide C6H5NH(COCH3)
· Product of acetylation of aniline with acetic anhydride
at low temperature.
· A white, odorless flakes solid or crystals
· Boiling point is 304C
· Melting Point: 114C –116C
· Density: 1.219 g/mL
Acetanilide C6H5NH(COCH3)
· Soluble in hot water, alcohol, ether, chloroform,
acetone, glycerol and benzene.
Acetanilide C6H5NH(COCH3)
· Used as precursor in penicillin synthesis and others
(pain killers and intermediates)
· A prodrug with analgesic and antipyretic properties
· Direct application may cause methemoglobinemia
and damage liver and kidneys.
Acetanilide C6H5NH(COCH3)
· Most useful and modern mean of separating mixture
for purification.
Chromatography
Medium fixed in the system
Stationary phase
· medium the flows through the fixed
medium.
Mobile phase
· Based on differences in the solubility of the substance and impurity in a given solvent.
Filtration
