Study Set Content:
formed by crystallization of the host molecules, the guest component is usually limited to long, unbranched straight chain compounds
Channel types
cage like lattice in which the coordinating compound is entrapped
Clathrates
– entrapment of a single guest molecule in the cavity (hydrophilic in nature).
Monomolecular types
is used to divide the particulate material into size and weight of these fractions
Sieve analysis
The particle size distribution is defined via the
mass or volume
t is based on the grading of different sizes of particles by using
different standard sieves.
The method involves shaking the sample powder for a
standard period of time
For accurate analysis, a set of sieves are arranged in a nest, and the accurately weighed sample is allowed to pass through the
sieves
After a definite period of time, the powder retained in each sieve is
weighed
Pharmacokinetic and Pharmacodynamic aspect: Complexation between drug and complexing agents can either (blank) drug absorption or bioavailability
improve or impair
Polyethylene glycol CHELATING/COMPLEXING AGENT
Salicylic acid, ASA, Phenobarbital
Povidone
Benzoic acid, salicylic acid, sodium salicylate, chloramphenicol
Sodium Carbomethylcellulose
Quinine, Procaine
Oxytetracyline & Tetracyline
Sodium salicylate, Sodium saccharine, Caffeine
95% powder passes from the no. 1400 sieve
Coarse powders
95% powder passes from the no. 180 sieve
Fine powders
95% powder passes from the no. 300 siev
Moderate fine powders
40 MCC (g)
13
50
7.4
85
4.7
