Study Set Content:
Chemically induced neoplasia can involve () that are derived from hepatocytes, bile duct progenitor cells, the ductular “bipolar” progenitor cells, and the periductular stem cells.
Tumors
are highly malignant angiosarcomas are derived from sinusoidal lining cells.
Angiosarcomas
has been linked to abuse of androgens, alcohol, and a high prevalence of aflatoxincontaminated diets.
Hepatocellular cancer
Fe overload Allyl alcohol
Zone 1 hepatocytes
Ccl4
Zone 3 hepatocytes
Acetaminophen
Zone 3 hepatocytes
Methylene dianiline, sporidesmin
Bile duct cells
Ethanol
Zone 3 hepatocytes
Cyclophosphamide, monocrotaline
Sinusoidal endothelium
Endotoxin, GDCl3
Kapfer cells
Vitamin A, Ethanol
Stellate cells
Preferential uptake and high oxygen levels
Fe(overload)
Higher oxygen levels for oxygen-dependent bioactivation
Allyl alcohol
More P450 enzyme for bioactivation
CCl4
More P450 isozyme for bioactivation and less GSH for detoxification
Acetaminophen
More hypoxic and greater imbalance in bioactivation, detoxification reactions
Ethanol
Exposure to the high concentration of reactive metabolites in bile
Methylene dianiline, sporidesmin
Greater vulnerability to toxic metabolites and less ability to maintain glutathione levels
Cyclophosphaide, monocrotaline
Preferential uptake and then activation
Endotoxin, GdCl3
Preferential site for storage and then engorgement
Vitamin A
