Study Set Content:
At higher doses, it may also stimulate alpha-2 and beta-1 adrenergic receptor
Phenylephrine
Antitussive
Dextromethorphan
At higher doses, it may also stimulate alpha-2 and beta-1 adrenergic receptor
Phenylephrine
Produces more toxicity than digitoxin due to greater VD and plasma protein binding
Digoxin (Foxglove)
Local anesthetic
Lidocaine
NSAID
Ibuprofen
binds to Na channels in nerve fibers, blocking the Na current responsible for nerve conduction, which will slow or block impulse generation giving the local anesthesia effect
Local anesthethic
Digoxin toxic dose Acute ingestion Child:
1mg
Adult
3 mg
Propranolol Usual daily adult dose
40-360mg
Propranolol Potentially life-threatening: Ingesting usual dose
2-3x
Phenylephrine Adult daily dose:
40-60 mg
Phenylephrine Children daily dose:
0.5-1mg/kg
Phenylephrine Toxicity
Children and adult will experience toxicity after ingestion of 2-3 times of the therapeutic doses
Dextromethorphan Toxic dose severe poisoning with ingestion of more than
20-30mg/kg
Lidocaine Maximum adult dose
300 mg only
Lidocaine Toxicity
Prolonged anesthesia
Ibuprofen ✮ Maximum daily adult dose:
3200mg
Digoxin leads to- () - () of vagal tone and slow sinus rate and () sinus and AV node conduction -() in atrial and ventricular automaticity due to accumulation of calcium
Hyperkalemia, Potentiation, decreased , Increase
Digoxin acute overdose
N/V, hyperkalemia and cardiac arrhythmia
